Protein Details: Cation channel sperm-associated protein 4

Protein ID

ICDB_Pro_1222

Protein Name

Cation channel sperm-associated protein 4

Gene Name

Catsper4

Organism

Mus musculus (Mouse)

Length

442 amino acids

AlphaFoldDB

AF-Q8BVN3-F1-model_v4.pdb

Function

Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility; a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization.

Sequence

MSEKHKWWQQVENIDITHLGPKRKAYELLGRHEEQVLINRRDVMEKKDAWDVQEFITQMYIKQLLRHPAFQLLLAFLLLSNAITIALRTNSYLGQKHYELFSTIDDIVLTILICEVLLGWLNGFWIFWKDGWNILNFAIVFILFMGFFIKQLDMVAITYPLRVLRLVHVCMAVEPLARIIKVILQSMPDLANVMALILFFMLVFSVFGVTLFGAFVPKHFQNMGVALYTLFICITQDGWLDIYTDFQMDEREYAMEVGGAIYFAVFITLGAFIGLNLFVVVVTTNLEQMMKTGEEEGHLNIKFTETEEDEDWTDELPLVHCTEARKDTSTVPKEPLVGGPLSNLTEKTCDNFCLVLEAIQENLMEYKEIREELNMIVEEVSSIRFNQEQQNVILHKYTSKSATFLSEPPEGANKQDLITALVSREKVSDSNINMVNKHKFSH

PDB Structures

7EEB

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Testis-specific

DOI ID

10.1126/science.1112014; 10.1371/journal.pbio.1000112; 10.1101/gr.2596504; 10.1095/biolreprod.105.045468; 10.1093/molehr/gam009; 10.1095/biolreprod.107.060186; 10.1073/pnas.0610286104; 10.1038/nature09767; 10.1038/ncomms1153; 10.1038/s41586-021-03742-6

RefSeq

NP_001123502.1; NP_808534.1